sqlite - ReflectionTypeLoadException on Me.Adapter.Fill(dataTable) when upgraded from .Net Framework 3.5 -

upgrading net framework 3.5 4 or 4.5 or 4.6 , code hangs on trivial me.adapter.fill(datatable) statement. if run code on x86 platform, code hangs without error. if pause compile procedure can find blocked in statement. if run on x64 platform stops in same code

reflectiontypeloadexception occurred

unable load 1 or more of requested types. retrieve loaderexceptions property more information

(break on clr enabled), compiles ok. compiles on x64 visual studio hosting process enabled. happened?